- Prof. D. Olivieri who was our guest speaker gave a presentation on “Immunology of COPD exacerbations and role of immunomodulators” , he highlighted on Lung immune defense mechanisms in healthy subjects and COPD patient. - Also, Clinical relevance of exacerbations in COPD, Microbiome and microbial-host relationships in the lung were also discussed. - Rationale for the prevention of COPD exacerbations by Broncho-Vaxom: experimental data & clinical studies. - He presented Broncho-Vaxom recent clinical studies (Soler 2007, Li 2004, Collet 1997, Orcel 1994, Tang 2015) and its impact on the reduction of COPD exacerbations. - Recommendation of Broncho-Vaxom in EPOS 2012 guidelines to be GRADE: A hence, there is a strong relation between the nose and the lungs. As well as, Broncho-Vaxom Safety profile and Recent Abstract on Broncho-Vaxom in COPD; systematic review and meta-analysis.

- Prof. Tarraf gave a fruitful speech on “Prevention of Exacerbations, thinking beyond the Guidelines”. - He gave a brief on Lung immune defence mechanisms in healthy subjects and COPD patient. - Definition of exacerbations according GOLD guidelines, risk factors of COPD and Managing exacerbations were also discussed. - He also talked about Factors associated with late recovery from exacerbations, Frequent Exacerbations which are Associated with Reduced Quality of Life and Prevention of exacerbation through (Influenza Vaccine, Anti-pneumococcal Vaccine and Broncho-Vaxom). - He highlighted on the mechanism of action of Broncho-Vaxom and the recent trial which is on COPD; systematic review and meta-analysis.