In the Metronidazole original product monograph, it was stated that: Comparison of the pharmacokinetics of oral and I.V. metronidazole, revealed that the area under the plasma metronidazole concentration against time curves were essentially identical.

A- Ciprodiazole is a fixed combination. B- According to IDSA guidelines the recommended dose of Metronidazole is between 2– 3 times daily according to the case. C-According to the study "Disposition of Metronidazole in Asian surgical patient the elimination half-life was longer compared with those for healthy volunteers,“ C- We do not have studies on patients receiving 2 tablets per day but we found the following important data from the product monograph of Metronidazole and other sources: “The elimination half-life was approximately 7 to 8 hours.” The trough to peak ratio of Metronidazole was 12 and 26 mg/L respectively. The MIC ( Minimum inhibitory concentration) of Metronidazole is equal or lower to 8mg/L. From that we conclude that the trough score of Metronidazole was 12 mg/L while the dose recommended for susceptible effect was 8 mg/L during the half life of 7-8 hours and the half life of ill patients was longer than normal which means that 2 tablets per day would be effective with these patients.

According to the study presented to in the brochure : The combination has superior efficacy compared to monotherapy. The combination has better compliance to the patient and thus higher adherence level. The tablet is scored for flexible dosing according to your need. The box is formed from 2 strips. Finally Ciprodiazole has a very competitive price when compared to other combinations in the market

Metronidazole is present in the market long before Tinidazole . The number of studies done on Metronidazole was extremely high versus Tinidazole. According to a study published in Am J Obstet Gynecol. 2011 March : “There were no differences in cure rates between metronidazole and tinidazole . In addition, there were no important differences between the side effect profiles of metronidazole and tinidazole.”