Composition:

Each Bon-One® tablet contains 0.25, 0.5 or 1.0 pg of alfacalcidol.

Indications:

* Improvement of various symptoms (hypocalcemia, tetany, bone pain, bone lesions, etc.) due to abnormal vitamin D metabolism in the following conditions:

- Chronic renal failure

- Hypoparathyroidism

- Vitamin D-resistant rickets and osteomalacia

* Osteoporosis

Dosage and Administration:

The dose should be adjusted with careful monitoring of the serum Ca level.

* Chronic renal failure and osteoporosis: For adults, 0.5 — 1.0 pg, as alfacalcidol, of Bon-One® tablet is generally administered orally once a day. The dose should be adjusted according to the age of the patients and the severity of symptoms.

* Hypoparathyroidism and other diseases associated with abnormal vitamin D metabolism: For adults, 1.0 — 4.0 pg, as alfacalcidol, of Boo-One® tablet is generally administered orally once a day. The dose should be adjusted according to the dieases, age of the patients, severity of symptoms, and the type of the diseases.

Dosage for children:

The general oral dose for children with osteoporosis ranges 0.01 —0.03 jig/ kg as alfacalcidol once a day, and that for the other indications ranges 0.05 — 0.1 pg/ kg as alfacalcidol once a day. The dose should be adjusted according to the diseases and the severity symptoms.