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Bon-One ® 0.25 µg Tablets

Bon-one tablet is the only brand Alfacalcidol tablet worldwide. Alfacalcidol increases Calcium absorption from the GIT, suppresses PTH secretion, thus decreasing bone resorption and enhancing bone repair.

Ingredient: Alfacalcidol
Multinational Partner: Teijin Pharma Limited
Launch Date: May 22, 2005
Pack: 30 tablets

Product General

Disease Area
  •  Bone is a living, growing tissue made up of cells, vessels and crystals of calcium compounds.
  •  Bone is remodeled throughout life. Remodeling is the process in which bones are broken down then built back up again through bone formation.
  •  10% of skeletal bone gets replaced this way each year.

Osteoporosis comes from Greek name meaning porous bone. It occurs when there is an imbalance between bone breakdown and bone formation, causing the bone to become very weak and spongy, increasing its liability for break and fracture.

Insert leaflet

Composition:

Each Bon-One® tablet contains 0.25, 0.5 or 1.0 µg of alfacalcidol.

Indications:

  • Improvement of various symptoms (hypocalcemia, tetany, bone pain, bone lesions, etc.) due to abnormal vitamin D metabolism in the following conditions:
    • Chronic renal failure
    • Hypoparathyroidism
    • Vitamin D resistant rickets and osteomalacia
  • Osteoporosis

Dosage and Administration:

The dose should be adjusted with careful monitoring of the serum Ca level.

  • Chronic renal failure and osteoporosis: For adults, 0.25 — 1.0 µg, as alfacalcidol, of Bon-One® tablet is generally administered orally once a day. The dose should be adjusted according to the age of the patients and the severity of symptoms.
  • Hypoparathyroidism and other diseases associated with abnormal vitamin D metabolism: For adults, 1.0 — 4.0 µg, as alfacalcidol, of Bon-One® tablet is generally administered orally once a day. The dose should be adjusted according to the dieases, age of the patients, severity of symptoms, and the type of the diseases.

Dosage for children:

The general oral dose for children with osteoporosis ranges 0.01 —0.03 µg/ kg as alfacalcidol once a day, and that for the other indications ranges 0.05 — 0.1 µg/ kg as alfacalcidol once a day. The dose should be adjusted according to the diseases and the severity symptoms.

Publications

1-Documents Section

Arch Intern Med 2008


AAc Rheuma Int 2009


j Am Soc Neph 07


Kidney International 2006


Nephrol Dial Transplant 2004


Reduction of Falls in Elderly The central role of Alfacalcidol in a multi-dimensional paradigm

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Office Address

Address: El-Bardissi St., 2T Takseem Asmaa Fahmy St., Heliopolis, Cairo - Egypt.
Phone: (+202) 2414-3170/1/2/3/4/5
Fax: (+202) 2414-3179

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